What is Mitragynine Pseudoindoxyl?

If you love kratom, you also love its secret ingredients – active ingredients known as alkaloids, which are responsible for the plant’s effect on the mind and body. The king of kratom alkaloids is mitragynine, and it’s likely the chemical you’ve seen the most buzz about in kratom-loving circles. But there are other alkaloids working behind the scenes to make the magic of kratom happen, including the newly explored mitragynine pseudoindoxyl. 

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But wait – what is mitragynine pseudoindoxyl, exactly? How does it differ from other kratom compounds? Below, we explore the facts about this potent alkaloid, including how it forms, what it does to the body, and how you can start experimenting with it. Let’s get started!

What is Mitragynine?

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To understand mitragynine pseudoindoxyl, you’ll need to know its predecessor, the primary alkaloid in kratom: mitragynine. It’s the primary alkaloid found in kratom leaves, along with 7-hydroxymitragynine (7-OH). 

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These compounds are responsible for the characteristics we associate with kratom, particularly its analgesic (pain-relieving), relaxing, and stimulating effects. Mitragynine is best known, however, for acting like an opioid to relieve pain.

What is Mitragynine Pseudoindoxyl?

Mitragynine pseudoindoxyl is another chemical compound that hails from the kratom plant. But unlike mitragynine, this compound doesn’t occur naturally in the leaves themselves – it’s actually a metabolite, meaning it forms when your body metabolizes (or breaks down) kratom.

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Through a process known as oxidative metabolism, mitragynine converts into metabolites, including mitragynine pseudoindoxyl. 

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7-OH is another metabolite of mitragynine, but it’s not the same thing as mitragynine pseudoindoxyl. In fact, 7-OH can actually be rearranged into mitragynine pseudoindoxyl – in other words, its chemical “pieces” can go through rearrangement, resulting in a new finished “puzzle” that is mitragynine pseudoindoxyl. 

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All of this is to say that mitragynine pseudoindoxyl is sort of like a “second generation” of the main alkaloid in kratom, mitragynine. It’s also a much more potent and powerful alkaloid. Mitragynine pseudoindoxyl is known for its enhanced analgesic effects, though more research is needed to fully understand how those effects stack up to other kratom alkaloids. 

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Like its predecessors, mitragynine pseudoindoxyl also acts on opioid receptors as both an agonist (at mu-opioid receptors) and an antagonist (at delta-opioid receptors). It effectively relieves pain without the same risks as current opioid therapies, as it’s not known to lead to physical dependence or respiratory depression. 

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While mitragynine pseudoindoxyl may not be abundant in plants, it’s possible to synthesize the compound in a lab, allowing manufacturers to use it to enhance kratom products. 

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Researchers have begun to develop reliable methods for synthesizing mitragynine pseudoindoxyl and new analogs of the alkaloid. This ongoing research may potentially lead to the development of new or improved pain-relieving medications that use kratom’s natural compounds for good.

Mitragynine Pseudoindoxyl vs. 7-OH

We know that both mitragynine pseudoindoxyl and 7-OH-mitragynine are both metabolites of the same parent: plain ol’ mitragynine. But it’s important to distinguish the two, as they’re not exactly the same in terms of potency.

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To understand why, let’s quickly review what 7-OH is. After you ingest kratom, your body – specifically your liver – breaks down or “metabolizes” mitragynine, turning it into the much stronger 7-hydroxymitragynine. It is this process that allows kratom to deliver much of its pain-relieving effects.

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You can think of 7-OH as a purer and more powerful form of mitragynine. It’s nearly 40 times as powerful as mitragynine, which is already significantly more potent than morphine! 

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Once again, 7-OH can become mitragynine pseudoindoxyl through a rearrangement process. Mitragynine pseudoindoxyl also forms from mitragynine itself. In a way, all three of these alkaloids are relatives – they have similar backgrounds, but their chemical structures are unique enough to set them apart. 

Potential Benefits of Mitragynine Pseudoindoxyl

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More research is needed before we can make any claims about the specific and unique benefits of mitragynine pseudoindoxyl. As it stands, it’s difficult to determine which potential benefits are due to the alkaloid itself and which could be caused in part by other kratom alkaloids, like 7-OH. However, we can confidently say that the observable benefits of mitragynine pseudoindoxyl closely mirror the benefits of kratom itself:

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• Pain Relief: Due to its strong analgesic properties, mitragynine pseudoindoxyl kratom products could be a natural alternative for pain management. For those who can’t or don’t want to use traditional opioid therapies – or are going through opioid withdrawals – an option like kratom can be a game-changer. This is especially true when you consider that mitragynine and mitragynine pseudoindoxyl are both stronger than morphine and come with fewer serious side effects.
• Mood Enhancement: Whether through direct influences on neurotransmitters like dopamine and serotonin or through indirect means (like reducing pain), mitragynine and its metabolites can boost your mood. Kratom is well-known as a tool for stress relief, improving overall wellness, and injecting some extra joy into your routine.
• Improved Focus & Cognition: While it can also be a sedative, kratom also has the ability to act as a stimulant, increasing your focus, alertness, and motivation.

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Over time, we may discover that mitragynine pseudoindoxyl has unique properties that make it especially beneficial. It might, for example, be better at treating pain than other alkaloids, or it may be less likely to cause side effects than things like 7-OH.

Mitragynine Pseudoindoxyl Side Effects

We still have a lot to learn about the effects of mitragynine pseudoindoxyl, and that includes its side effects. Once again, it’s tricky to parse out which side effects are from which metabolite or alkaloid when you consume kratom. It’s safe to assume, though, that you could experience side effects that are characteristic of kratom, such as:

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• Nausea or vomiting
• Irritability
• Insomnia
• Constipation
• Drowsiness or sedation

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In extreme cases, kratom and its alkaloids can cause more severe side effects, like hallucinations, delusions, and even seizures. That’s why it’s important to check with your doctor before you start using kratom or any other natural supplement. It’s also important to start with low, controlled doses and slowly work your way up to higher doses as needed.

Explore Your Favorite Kratom Alkaloids at The Green Dragon CBD

When it comes to mitragynine pseudoindoxyl, researchers and kratom enthusiasts alike have only scratched the surface. We know some key details about this compound, but there’s still a lot we don’t know about its unique interactions with the mind and body. 

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We can say that this kratom metabolite is especially potent and great at relieving pain, which means that those looking for a natural pain-relief solution may want to seek products enhanced with extra alkaloids. 

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Whether you intentionally seek it out or not, mitragynine pseudoindoxyl will likely make its way into your system at some point if you consume kratom. Take note of how different product and strain types affect you to learn which options are the most effective for your lifestyle and goals.

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No matter what kind of kratom you’re looking for, you can count on Green Dragon to help you find just what you need. Shop our collection of kratom alkaloid products to add an extra edge to your routine, target pain symptoms, and take control of your day. 

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Not sure where to get started? We’ve got your back. Reach out to our team at any time to ask questions or receive a free consultation!